Key result
Carotid body denervation in anesthetized mice reduced minute ventilation during normoxia, caused ventilatory depression during hypoxia, and lowered ventilatory responses during hypercapnia.
The carotid bodies are essential for maintaining ventilation during eupnea, hypoxia, and hypercapnia in anesthetized mice.
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Findings in anesthetized mice warrant caution before clinical translation; leaves open carotid body roles in awake states or humans.
Izumizaki et al. (2004) studied Spontaneously breathing urethane-anesthetized mouse. Carotid body denervation vs. Before denervation (intact sinus nerves) was evaluated on Ventilatory responses to normoxia, hypoxic hypoxia, and hyperoxic hypercapnia. Carotid body denervation in anesthetized mice reduced minute ventilation during normoxia, caused ventilatory depression during hypoxia, and lowered ventilatory responses during hypercapnia.
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