November 1, 1986The Journal of PhysiologyOpen Access

Restoration of hypoxic respiratory responses in the awake rat after carotid body denervation by sinus nerve section.

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Population

28 awake rats

Comparison

Bilateral carotid sinus nerve section followed… vs Pre-denervation response and responses at 1 day…

Design

Preclinical

Follow-up

up to 192 days

Authors

RMR.L. Martin-BodyUniversity of Auckland GRG J Robson JSJ. D. SinclairMayo Clinic

Discussion

Member takes

Implication

Hypothesis-generating for central compensation after carotid body loss in rats; leaves open human translational relevance.

Structured PICO

Population

28 awake rats

Intervention

Bilateral carotid sinus nerve section (carotid body denervation) followed by bilateral section of glossopharyngeal, abdominal vagal, and aortic depressor nerves

Comparator

Pre-denervation response and responses at 1 day post-section

Outcome

Ventilatory responses to hypoxia (respiratory stimulation/depression at various partial pressures of inspired O2)surrogate

Central neural reorganization provides compensation for loss of carotid body function by enhancing the effects of normally subsidiary inputs in rats.

Cite This Study

Martin-Body et al. (1986) studied this question.

synapsesocial.com/papers/6a8b2f9095f0361a9ebebb06 https://doi.org/10.1113/jphysiol.1986.sp016272

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Restoration of hypoxic respiratory responses in the awake rat after carotid body denervation by sinus nerve section.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Restoration of hypoxic respiratory responses in the awake rat after carotid body denervation by sinus nerve section.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider