Why the study?
Does chronic carotid body denervation alter renin, ACTH, blood pressure, and hematocrit responses to hypercapnia and hypoxia in dogs?
Does chronic carotid body denervation alter renin, ACTH, blood pressure, and hematocrit responses to hypercapnia and hypoxia in dogs?
In a canine model, blood pressure and hematocrit responses to hypoxia are primarily carotid chemoreflexes, whereas the renin response to hypercapnia and hypoxia is not.
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Carotid denervation attenuates hypoxic BP and hematocrit but not PRA responses in dogs; leaves open chemoreflex mediation of renin in human cardiorenal disease.
Raff et al. (1984) studied this question.
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