Key result
Bilateral carotid body removal significantly reduced the hypoxic ventilatory response (∆91%, P<0.05) and systolic blood pressure response (∆71%, P<0.05) to hypoxia, while heart rate was unchanged.
Why the study?
Does bilateral carotid body removal alter the haemodynamic and ventilatory responses to hypoxia in men with systolic heart failure?
Population
6 men with systolic heart failure, median age 58.5 years, median ejection fraction 32%.
Comparison
Bilateral carotid body removal (CBR) vs Baseline (before CBR)
Design
Case_series
Follow-up
1 month
Authors
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Should not change practice in systolic HF; hypothesis-generating for distinct afferent pathways in hypoxic responses.
Observational (n=6)
Does bilateral carotid body removal alter the haemodynamic and ventilatory responses to hypoxia in men with systolic heart failure?
Effect estimate: ∆91% reduction in HVR, ∆71% reduction in SBP slope
p-value: p=<0.05
Bilateral carotid body removal in heart failure patients attenuates the blood pressure and ventilatory responses to hypoxia while preserving the heart rate response, indicating distinct sensory afferent pathways.
Niewiński et al. (2013) conducted an observational in Systolic heart failure (n=6). Bilateral carotid body removal vs. Before procedure was evaluated on Hypoxic ventilatory response and systolic blood pressure slope (∆91% reduction in HVR, ∆71% reduction in SBP slope, p=<0.05). Bilateral carotid body removal significantly reduced the hypoxic ventilatory response (∆91%, P<0.05) and systolic blood pressure response (∆71%, P<0.05) to hypoxia, while heart rate was unchanged.
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