Population
9 healthy subjects
Comparison
Carbon dioxide administration using short pulses… vs Steady-state response and rebreathing response
Design
Other
Authors
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Transient CO2 responses should not proxy steady-state gain; leaves open optimal method validation for ventilatory sensitivity assessment.
The transient ventilatory response to CO2 does not represent steady-state gain, and the rebreathing technique overestimates CO2 sensitivity near the control point.
Jacobi et al. (1989) studied this question.
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