Mucosal Melanoma of the Head and Neck

Mucosal melanoma (MM) is a rare, very aggressive noncutaneous melanoma that affects the upper aerodigestive tract, genitourinary tract, and anal/rectal region. 1 This portion of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck (H&N) Cancers only describes MMs of the H&N, which constitute fewer than 10% of melanomas of the H&N. Note that a separate NCCN Guideline is available for cutaneous melanoma (see NCCN Guidelines for Melanoma, available in this issue and online at www.NCCN.org).