Molecularly-imprinted polymer-base bulk optode for the determination of ivabradine hydrochloride in Procoralan®

Figures

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  Fig. 1. Structure of ivabradine hydrochoride.

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  Scheme 1. Steps of the preparation of the miptode to get the absorbance spectra.

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  Fig. 2. Calibration curves of the different sensors with error bars for three different measurements; (●) miptode 2, (○) nitpode 3, (▼) optode 4.

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  Fig. 3. AFM images of miptode 2; (A and B) planar images, and (C and D) 3D images.

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  Fig. 4. Spectra of miptode 2 in different IVH concentrations.

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  Fig. 5. Selectivity and response of miptode 2 for IVH and different interfering ions applying separate solution method.

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  Fig. 6. Selectivity of miptode 2 (black columns) and niptode 3 (grey columns) for IVH in the presence of different interfering ions using mixed solution method; (A) absolute value of the normalized absorbance of 10−4 M IVH+ 10−2 M interfering ion; (B) error bars of Fig. A that represent change in absorbance is more illustrated as columns.

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  Fig. 7. Reversibility and response time (A), and life time (B) of the miptode.2.

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  Fig. 8. Sensor-to-sensor variation of miptode 2, (black columns) the absolute values of normalized absorbance, (red columns) the change in normalized absorbance when move from low to higher concentration, inset is the calibration curve with error bars for two different sensors.