Key result
Obesity was associated with significantly lower early and late 123I-MIBG heart-to-mediastinum ratios in heart failure patients compared to non-obese subjects, whereas prone-position acquisition did not change these indexes.
Why the study?
Does prone-position acquisition compared to supine-position alter 123I-MIBG indexes of cardiac sympathetic innervation in patients with heart failure?
Cross-Sectional (n=45)
No
Does prone-position acquisition compared to supine-position alter 123I-MIBG indexes of cardiac sympathetic innervation in patients with heart failure?
Obesity significantly reduces 123I-MIBG indexes of cardiac sympathetic innervation in HF patients, but prone-position acquisition does not alter these indexes compared to standard supine imaging.
Answers are grounded in this paper and cite their sources.
Prone acquisition should not yet change 123I-MIBG protocols in HF; this Level 4 study leaves open its utility in obese patients.
BACKGROUND: This study was designed to assess the impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine (MIBG) indexes of cardiac sympathetic innervation. METHODS: Forty-five patients with heart failure (HF) (38 men, age 58±15 years) underwent (123)I-MIBG cardiac imaging. Of these patients, 10 were obese [body mass index (BMI) ≥30 kg/m(2)]. Ten-minute planar images of the thorax in anterior view were performed 15 minutes ("early" image) and 3 hours and 50 minutes ("late" image) after tracer administration in both supine- and prone-position. Early and late (123)I-MIBG heart-to-mediastinum (H/M) ratios and washout rate were computed. RESULTS: In overall study population, early and late (123)I-MIBG H/M ratios and washout rate were comparable between supine- and prone-position acquisitions. Obese patients had a lower early and late (123)I-MIBG H/M ratios both in supine (P<0.01) and prone (P<0.05) positions compared to non-obese subjects. CONCLUSIONS: Our results indicate that in HF patients, obesity has a significant impact on (123)I-MIBG indexes of cardiac sympathetic innervation. Prone-position did not change early and late (123)I-MIBG H/M ratios and washout rate compared to supine position both in obese and non-obese HF patients.
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Pellegrino et al. (2015) conducted a cross-sectional in Heart failure (n=45). Obesity (BMI ≥30 kg/m2) vs. Non-obese (BMI <30 kg/m2) was evaluated on Late 123I-MIBG heart-to-mediastinum (H/M) ratio in supine position (p=<0.01). Obesity was associated with significantly lower early and late 123I-MIBG heart-to-mediastinum ratios in heart failure patients compared to non-obese subjects, whereas prone-position acquisition did not change these indexes.
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