Key result
Acquisition parameters, including collimator type and acquisition duration, along with patient characteristics, independently explained 31% of the variation in late 123I-MIBG heart-to-mediastinum ratios (p<0.001).
Why the study?
Do acquisition parameters and patient characteristics independently predict the variation in late heart-to-mediastinum ratio in 123I-MIBG imaging in patients with chronic heart failure?
Population
290 chronic heart failure patients, 82% male, 58% dilated cardiomyopathy, from six sites in five European…
Design
Cohort
Authors
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May warrant caution interpreting 123I-MIBG H/M ratios across sites; leaves open whether standardization improves HF risk stratification.
Observational (n=290)
Yes
Do acquisition parameters and patient characteristics independently predict the variation in late heart-to-mediastinum ratio in 123I-MIBG imaging in patients with chronic heart failure?
Effect estimate: Adjusted R2 0.312
p-value: p=<0.001
Acquisition parameters such as collimator type and acquisition duration independently contribute to the variation in semi-quantitative measurements of cardiac 123I-MIBG uptake, highlighting the need for standardization.
Verberne et al. (2007) conducted an observational in Chronic heart failure (n=290). 123I-MIBG imaging acquisition parameters was evaluated on Variation in late heart-to-mediastinum (H/M) ratio (Adjusted R2 0.312, p=<0.001). Acquisition parameters, including collimator type and acquisition duration, along with patient characteristics, independently explained 31% of the variation in late 123I-MIBG heart-to-mediastinum ratios (p<0.001).
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