Key result
Premature birth with very low/extremely low body weight was associated with changes in the transmural wall strain gradient and decreased LV longitudinal strain in children aged 1-5.
Why the study?
Premature newborns are more susceptible to cardiovascular disease long-term, and assessing LV deformation could identify subclinical myocardial impairment.
Does premature birth with very low and extremely low body weight impair left ventricle longitudinal strain in children aged 1 to 5 years compared to full-term children?
Observational (n=131)
Does premature birth with very low and extremely low body weight impair left ventricle longitudinal strain in children aged 1 to 5 years compared to full-term children?
Children born very premature with very low body weight show subclinical myocardial impairment detectable by changes in LV longitudinal strain, suggesting a need for modified outpatient monitoring.
Answers are grounded in this paper and cite their sources.
Layer-specific LV strain may detect subclinical impairment in preterm children; leaves open its prognostic value and need for prospective validation.
Background. In last decades, the number of babies born preterm has increased significantly. Premature newborns are more susceptible to cardiovascular disease in the long-term. To identify subclinical myocardial impairment in premature infants, an assessment of of the left ventricle (LV) deformation could be used.Objective. The aim of the study was to study the left ventricle (LV) Longitudinal Strain of the endocardial, middle and epicBardial layers in children born with very low and extremely low body weight, at the age from one to five years.Design and methods. The study included 88 children aged from one to 5 years old, born very premature with very low and extremely low body weight. The comparison group consisted of 43 healthy children of the same age, born full-term. The LV Longitudinal Strain of the endocardial, middle and epicardial layers was studied using the Speckle Tracking Imaging-2D Strain.Results. In children aged 1 to 5 years, born with very low and extremely low body weight, changes in the gradient of transmural wall Strain and a decrease in LV segments longitudinal strain were detected in 15.90 % and 14.77 % of cases, respectively. Mothers of children born prematurely and who subsequently registered disturbance of the transmural gradient of left ventricular strain in 10 cases (71.43 %) had a history of threatened termination of pregnancy. The threat of termination of pregnancy was noted in all women whose children had a decrease in LV segmental strain. In children who have normal of LV segmental strain, the threat of termination of pregnancy in mothers was registered in 16 cases (26.23 %). LV remodeling is observed in children with a change in the gradient of transmural wall strain or and with a decrease in LV longitudinal segment strain. Conclusion. Changes in the transmural gradient of wall deformation or reduction of segmental LV deformation in the longitudinal direction in premature infants require correction of the conventional algorithm of dispensary observation in an outpatient setting.
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Pavlyukova et al. (2021) conducted an observational in Premature birth with very low and extremely low body weight (n=131). Premature birth with very low and extremely low body weight vs. Healthy full-term children was evaluated on Changes in the gradient of transmural wall strain. Premature birth with very low/extremely low body weight was associated with changes in the transmural wall strain gradient and decreased LV longitudinal strain in children aged 1-5.
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