Why the study?
Coxsackievirus 6 has emerged as a major cause of hand, foot and mouth disease outbreaks, leading to more severe illness and unique findings compared with typical viral strains.
Coxsackievirus 6 is increasingly causing atypical and more severe presentations of hand, foot and mouth disease.
CV6 predominance in HFMD links to atypical severity; leaves open needs for updated surveillance and pediatric management trials.
Hand, foot and mouth disease (HFMD) is a viral illness caused most commonly in the past by coxsackievirus A16 and enterovirus 71. The disease mainly affects paediatric populations younger than 5 years of age and is characterized by lesions of the oral mucosa, palms and soles, lasting for 7–10 days. In recent years, coxsackievirus 6 has become a major cause of HFMD outbreaks in Ireland and worldwide. This strain causes more severe disease with unique findings compared with typical viral strains. We review the increasing presentation of patients with atypical cases in our institution and the implications.
No takes yet. Share an insight, caveat, or question.
Griffin et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: