Why the study?
What is the rate of non-responders to clopidogrel in hip fracture patients, and does clopidogrel treatment affect bleeding and adverse events compared to controls?
Population
112 patients with acute proximal femoral fracture, including 28 cases on clopidogrel treatment and 84…
Comparison
Clopidogrel treatment vs No clopidogrel treatment (84 controls)
Design
Case-control
Follow-up
Up to 3 months after surgery
Authors
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No difference in bleeding despite 29% clopidogrel non-responders; hypothesis-generating for responder testing in hip fracture surgery.
What is the rate of non-responders to clopidogrel in hip fracture patients, and does clopidogrel treatment affect bleeding and adverse events compared to controls?
Almost one-third of hip fracture patients on clopidogrel are non-responders, suggesting they may undergo surgery without delay as bleeding risks do not significantly differ.
Anna Clareus (2015) studied this question.
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