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A series of 2‐(1‐alkenyl)‐3‐hydroxy‐1,4‐naphthoquinones has been prepared and their toxicities assessed against Musca domestica. By comparison with analogous compounds having saturated 2‐alkyl substituents, or unsaturated substituents with an unconjugated double bond (e.g. lapachol), it was demonstrated that the α‐unsaturation of the substituent is responsible for a significant increase in the toxicity. The effect of the compounds against several other insect species and Tetranychus urticae follows completely different patterns.
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Jacobsen et al. (1986) studied this question.
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