The natural pyran-naphthoquinone (I,II) has been reported as an agent against Trypanosoma Cruzi and some kinds of tumors1,2,3. We hav recently reported a new synthesis of substituted pyran-naphthoquinone (III) by alkylation of 2-hyoxy-1,4-naphthoquinone with some natural mono-erpenes (citral, farnesal and phytal) followed by hydrogenation3.
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Ferreira et al. (1982) studied this question.
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