Rh-Catalyzed Coupling of Cyclic 1,3-Dicarbonyl-Derived Iodonium Ylides with Cyclopropanols

Herein, we report a modular α-monoalkylation of cyclic 1,3-dicarbonyls with cyclopropyl alcohols through a cyclic iodonium ylide strategy. This approach is general, base-free, operationally simple, and suitable for various medically important (hetero)cyclic 1,3-dicarbonyls. A wide range of cyclopropyl alcohols, easily prepared from feedstock chemicals, can serve as modular and complement alkylating agents. Importantly, the newly formed carbonyl groups in the resulting products provide a versatile platform for numerous synthetic applications.