Why the study?
The study was conducted to examine the effects of a 12-wk in-home self-monitored physical activity program on endothelial reactivity, arterial stiffness, sedentary behaviors, and upright and stepping activities in individuals with asymptomatic peripheral arterial disease.
Does a 12-week in-home self-monitored physical activity program improve endothelial reactivity, arterial stiffness, and physical activity levels in individuals with asymptomatic peripheral arterial disease?
Does a 12-week in-home self-monitored physical activity program improve endothelial reactivity, arterial stiffness, and physical activity levels in individuals with asymptomatic peripheral arterial disease?
A 12-week in-home physical activity program modestly improves microvascular reactivity and physical activity levels, while reducing sedentary behavior, in patients with asymptomatic peripheral arterial disease.
May improve microvascular reactivity in APAD; leaves open larger trials on clinical outcomes.
PURPOSE: The purpose of this study was to examine the effects of a 12-wk in-home self-monitored physical activity (PA) program targeting a combination of lifestyle PA program on changes in endothelial reactivity, arterial stiffness, sedentary behaviors, and upright and stepping activities in individuals with asymptomatic peripheral arterial disease (APAD). METHODS: Participants (n = 38) with APAD (ages 52-87 yr) were randomized to attention control (AC) or a PA sedentary reduction (PASR) group using an interactive online 3-month program focusing on increasing lifestyle PA and decreasing sedentary behaviors. The ActivPal™ PA monitor was used to measure postural and stepping parameters. Endothelial reactivity (peripheral arterial tone-reactive hyperemia index [PAT-RHI]) and augmentation index (AIx) were measured using the EndoPAT™ system at baseline and 3 months. RESULTS: The PASR group significantly decreased daily sit/lie hours (-0.80 ± 0.87 vs 0.18 ± 0.77 P = 0.001), increased sit-to-stand transitions per day (7.1 ± 10.5 vs -1.4 ± 5.71, P < 0.001), and increased daily step counts (2814 ± 1753 vs 742 ± 1321, P < 0.001). The PASR group also increased steps per day accumulated within specific cadence bands 61-80 steps per minute (1252 ± 447 vs 177 ± 359, P < 0.001), 81-100 steps per minute band (919 ± 511 vs -98 ± 697, P < 0.001), and within the 101-120 steps per minute band (415 ± 625 vs -327 ± 467, P < 0.001) versus the AC group. PAT-RHI significantly increased in the PASR group (0.179 ± 0.180 vs 0.0.044 ± 0.101, P = 0.019), whereas no significant changes were observed in PAT-AIx. CONCLUSIONS: Modest improvements in microvascular reactivity, PA, sedentary behavior, but not arterial stiffness were demonstrated after a 12-wk intervention targeting sedentary behavior reduction and increased lifestyle PA in individuals with APAD.
No takes yet. Share an insight, caveat, or question.
Laslovich et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: