Clinical relevance of serum omentin‐1 levels as a biomarker of prognosis in patients with acute cerebral infarction

BACKGROUND AND PURPOSE: Previous studies have shown that adipocytokines are associated with atherosclerosis, diagnosis, and functional prognosis after ischemic stroke. However, few studies have investigated the relationship between omentin-1 and atherosclerotic acute cerebral infarction (ACI). METHODS: In this study, we investigated the association between serum omentin-1 levels at admission and severity, infarction volume, and functional prognosis of patients 90 days after atherosclerotic ACI. RESULTS: A total of 109 patients with atherosclerotic ACI were enrolled. Serum omentin-1 levels at admission were lower in patients with ACI than those in healthy controls (47.18 ± 13.64 vs. 56.27 ± 34.44 ng/ml, p = .014). Serum omentin-1 levels at admission were negatively correlated with severity of ACI (r = -.271, p = .004) and infarction volume (r = -.264, p = .006), respectively. Moreover, serum omentin-1 levels were lower in the poor functional prognosis group than those in the good functional prognosis group in patients with large artery and small artery atherosclerotic ACI. In a logistic regression analysis, higher serum omentin-1 level (>43.10 ng/ml) at admission was negatively associated with a poor functional prognosis 90 days after atherosclerotic ACI. CONCLUSIONS: Serum omentin-1 levels at admission were significantly lower among patients with ACI. A higher plasma omentin-1 level (>43.10 ng/ml) was negatively associated with poor functional prognosis 90 days after atherosclerotic ACI. Further studies are needed to investigate the pathophysiological mechanism of omentin-1 in affecting attacks and prognosis of ACI as well as to confirm the value of plasma omentin-1 level as a potential biomarker.