Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 2016Journal of Pharmacy and Pharmacology

Exogenous hydrogen sulphide ameliorates diabetic cardiomyopathy in rats by reversing disordered calcium-handling system in sarcoplasmic reticulum

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does exogenous hydrogen sulphide improve diabetic cardiomyopathy by reversing disordered calcium-handling in sarcoplasmic reticulum in a rat model?

Population

Sprague Dawley rats with streptozotocin (STZ, 60 mg/kg, i.p.) induced diabetic model

Comparison

Sodium hydrogen sulphide vs Untreated diabetic model group and…

Design

Preclinical

Authors

DDDe‐Zai DaiYDYin DaiDZDongdong Zhu

Discussion

Loading...

Member takes

Overview

Should not yet change practice; leaves open hydrogen sulfide effects on calcium handling in diabetic cardiomyopathy.

Structured PICO

Does exogenous hydrogen sulphide improve diabetic cardiomyopathy by reversing disordered calcium-handling in sarcoplasmic reticulum in a rat model?

P
Population
Sprague Dawley rats with streptozotocin (STZ, 60 mg/kg, i.p.) induced diabetic model
I
Intervention
Sodium hydrogen sulphide (NaHS, 5 mg/kg per day, s.c.)
C
Comparator
Untreated diabetic model (DM) group and aminoguanidine group (AG, 100 mg/kg, p.o.)
O
Outcome
Cardiac dysfunction, myocardial hypertrophy, ROS levels, and expression of calcium-handling proteins in sarcoplasmic reticulumsurrogate

Exogenous hydrogen sulphide ameliorates diabetic cardiomyopathy in rats by inhibiting abnormal calcium-handling in the sarcoplasmic reticulum and the ET-NADPH oxidase-PKCε pathway.

Cite This Study

Dai et al. (2016) studied this question.

synapsesocial.com/papers/6a8b9875e6afc07dcbf455fbhttps://doi.org/10.1111/jphp.12517
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis2015 · 90 citations
  2. 2Effect of exenatide on the cardiac expression of adiponectin receptor 1 and NADPH oxidase subunits and heart function in streptozotocin-induced diabetic rats2014 · 20 citations
  3. 3Effect of exercise training on Ca2+ release units of left ventricular myocytes of spontaneously hypertensive rats2014 · 18 citations
  4. 4Effect of exercise training on Ca²⁺ release units of left ventricular myocytes of spontaneously hypertensive rats.2014 · 12 citations
  5. 5Fructose Modulates Cardiomyocyte Excitation-Contraction Coupling and Ca2+ Handling In Vitro2011 · 35 citations