Population
Isolated dog left ventricular (LV) and right ventricular (RV) midmyocytes, and anesthetized beagle dogs
Comparison
Isoproterenol with or without PDE3 and PDE4… vs Left ventricle versus Right ventricle responses
Design
Preclinical
Authors
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Animal data on RV-predominant beta-adrenergic effects should not change practice; leaves open PDE-targeted therapies for human right heart failure.
The right ventricle demonstrates enhanced beta-adrenergic responsiveness compared to the left ventricle due to decreased cAMP degradation by PDE3 and PDE4.
Molina et al. (2014) studied this question.
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