Population
HeLa cell nuclear extracts and HIV-1 RNA transcripts (SLS2-A7)
Design
Preclinical
Authors
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Hypothesis-generating for hnRNP K modulation in HIV; requires in vivo validation before therapeutic consideration.
The study identifies hnRNP K as a novel HIV-1 splicing regulator that negatively affects site A7 activity and reduces Nef protein production.
Marchand et al. (2011) studied this question.
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