Population
Murine ventricular myocytes and a heterologous expression system
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether PKCepsilon-TASK-1 signaling drives human repolarization disorders.
Activation of PKCepsilon regulates TASK-1 channels via threonine 381, leading to repolarization abnormalities in murine ventricular myocytes.
Besana et al. (2004) studied this question.
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