A Clinical and Histopathological Study on Nodular Median Rhomboid Glossitis

Five cases of nodular median rhomboid glossitis were clinicopathologically examined. The age of patients ranged from 47 to 60 years. The lesions appeared as an elevated oval or round lesion in the dorsal midline of the tongue. The lesion of 4 cases was excized and one biopsy was performed. Histopathologically, epithelial hyperplasia, subepithelial inflammation and thick band of hyalinized connective tissue were observed in all of the cases. Fungal hyphae were found in the parakeratoic layer in four cases. Nodular formation of the lesions was thought to be caused by proliferation of the epithelial and subepithelial tissue.