SPON1 Is Associated with Amyloid-β and APOE ε4-Related Cognitive Decline in Cognitively Normal Adults

Figures

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  Fig. 1. Rates of change in cognitively normal older adults. Rates of change are presented for (a) global cognition (SD/year), (b) verbal episodic memory (SD/year) and (c) AIBL-PACC (4×SD/year) in cognitively normal older adults (n = 590). SPON1A– (grey) and SPON1A+ (black). Controlling for APOE ɛ4 and amyloid-β status, AIBL-PACC analysis also controlled for age. Error bars represent time dependent standard error, *p < 0.05.

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  Fig. 2. Rates of change in cognitively normal adults stratified by amyloid-β status, APOE ɛ4 interaction. Rates of change are presented for (a, d) global cognition (SD/year), (b, e) verbal episodic memory (SD/year) and (c, f) AIBL-PACC (4×SD/year) in cognitively normal older adults with low (a, b, c; n = 336) or high (d, e, f; n = 254) amyloid-β. APOE ɛ4-ve/SPON1A– (green), APOE ɛ4-ve/SPON1A+ (blue), APOE ɛ4 + ve/SPON1A– (orange), APOE ɛ4 + ve/SPON1A+ (red). Controlling for age in AIBL-PACC. Error bars represent time dependent standard error. *p < 0.05 when comparing to the APOE ɛ4-ve/SPON1A– carrier group, †p < 0.05 when comparing to the APOE ɛ4-ve/SPON1A+ group, ‡p < 0.05 when comparing to the APOE ɛ4 + ve/SPON1A– carrier.