Why the study?
Does a single oral dose of 80 mg propranolol reduce physiological and psychological responses to experimental stress in healthy volunteers?
Does a single oral dose of 80 mg propranolol reduce physiological and psychological responses to experimental stress in healthy volunteers?
A single 80 mg dose of propranolol blunts the heart rate and systolic blood pressure response to acute stress in healthy volunteers without affecting subjective anxiety.
Attenuates physiological but not subjective stress responses in healthy volunteers; confirms acute beta-blocker effects but leaves clinical translation open.
The influence of beta-adrenoceptor antagonism on the effects of a single experimental stress was investigated in 12 healthy volunteers, using a double-blind protocol. A single oral dose of 80 mg propranolol reduced the stress-induced increase in heart rate and systolic blood pressure to 49.9 per cent and 8.3 per cent respectively compared to 61.0 per cent and 17.4 per cent with placebo. The rise in diastolic blood pressure was small and unaffected by beta-adrenoceptor blockade. The rise in temperature of the skin of the trunk was significantly reduced by propranolol. The self-rating of anxiety, alertness and concentration by the subjects was unaffected by propranolol.
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Taylor et al. (1981) studied this question.
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