January 1, 1977Catheterization and Cardiovascular Diagnosis
Effects of propranolol on coronary hemodynamic and metabolic responses to tachycardia stress in patients with and without coronary disease
Why the study?
Does propranolol alter coronary hemodynamics and metabolism during tachycardia stress when heart rate is controlled in patients with and without coronary disease?
Population
15 patients (10 with significant coronary narrowing [CAD] and 5 normal)
Comparison
Propranolol 10 mg IV vs Baseline during pacing-induced tachycardia stress
Design
Other
Authors
Discussion
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Member takes
Implication
Propranolol effects appear HR-dependent; leaves open direct coronary or metabolic actions in hypothesis-generating data.
Structured PICO
Does propranolol alter coronary hemodynamics and metabolism during tachycardia stress when heart rate is controlled in patients with and without coronary disease?
P
Population
15 patients (10 with significant coronary narrowing [CAD] and 5 normal)
I
Intervention
Propranolol 10 mg IV
C
Comparator
Baseline (before propranolol) during pacing-induced tachycardia stress
O
Outcome
Coronary hemodynamics and metabolism (systemic pressure, coronary sinus blood flow [CSBF], left ventricular oxygen utilization [LVVO2], ST segment depression, and myocardial lactate extraction)surrogate
The anti-ischemic and metabolic effects of propranolol are primarily secondary to its heart-rate lowering effects, suggesting tachycardia stress testing remains clinically useful in patients taking the drug.
Cite This Study
Schang et al. (1977) studied this question.