What question did this study set out to answer?

To identify lipidomic changes across human brain regions lacking severe neurodegeneration or Lewy body pathology, with a primary focus on the visual cortex in Parkinson's disease.

February 28, 2011PLoS ONEOpen Access

Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex

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To identify lipidomic changes across human brain regions lacking severe neurodegeneration or Lewy body pathology, with a primary focus on the visual cortex in Parkinson's disease.
Analyzed postmortem primary visual cortex, amygdala, and anterior cingulate cortex tissues from Parkinson's disease patients (n = 10) and controls (n = 10).
Screened 200 lipid species via liquid chromatography mass spectrometry and profiled enzymatic and non-enzymatic oxysterols using gas chromatography mass spectrometry.
Quantified the expression of lipid metabolism and oxidative stress response genes using quantitative polymerase chain reaction.
Identified significant alterations in 79 lipid species by unpaired t-test (p < 0.05), with 73 sphingolipids, glycerophospholipids, and cholesterol species retaining significance after false discovery rate analysis (q < 0.05) in the visual cortex.
Observed no lipid species that remained statistically significant after false discovery rate correction in the amygdala or anterior cingulate cortex.
Found selective increases in 6 of 7 oxysterols in the visual cortex, which correlated with altered expression of lipid metabolism and oxidative stress genes.

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Implication

Postmortem tissue study reveals extensive lipid pathway alterations and elevated oxysterols in the visual cortex in Parkinson's disease, suggesting early metabolic drivers of non-motor symptoms.

Cite This Study

Cheng et al. (2011) studied this question.

synapsesocial.com/papers/6a8ba94cdf3a83baf8caa847 https://doi.org/10.1371/journal.pone.0017299

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Implication

Postmortem tissue study reveals extensive lipid pathway alterations and elevated oxysterols in the visual cortex in Parkinson's disease, suggesting early metabolic drivers of non-motor symptoms.

Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex

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Cite This Study

Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex

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Implication

Cite This Study

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