January 1, 1998Journal of Cardiovascular Pharmacology

Ischemia and Left Ventricular Dysfunction: A Reciprocal Relation?

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Why the study?

Does congestive heart failure lead to impaired myocardial blood flow reserve and perfusion-metabolism mismatch?

Population

48 subjects: 12 patients with idiopathic dilated cardiomyopathy and 12 healthy controls; 24 patients with…

Comparison

Assessment of myocardial blood flow and… vs Healthy controls and CAD patients with normal LV…

Design

Cross-sectional

Authors

DVDirk J. van VeldhuisenUniversity Medical Center Groningen AHAd F. van den HeuvelUniversity Medical Center Groningen PBP. K. BlanksmaUniversity Medical Center Groningen

Discussion

Member takes

Implication

Impaired reserve in HF should not yet change practice; leaves open whether LV dysfunction causes or results from ischemia.

Structured PICO

Does congestive heart failure lead to impaired myocardial blood flow reserve and perfusion-metabolism mismatch?

Population

48 subjects: 12 patients with idiopathic dilated cardiomyopathy (normal coronary arteries) and 12 healthy controls; 24 patients with documented coronary artery disease (CAD) comparing those with normal LV function to those with LV dysfunction and congestive heart failure (CHF).

Intervention

Assessment of myocardial blood flow and metabolism using positron emission tomography (PET) with [13N]ammonia and [18F]fluorodeoxyglucose (18FDG) at rest and after dipyridamole infusion.

Comparator

Healthy controls (for cardiomyopathy patients) and CAD patients with normal LV function (for CAD patients with CHF).

Outcome

Myocardial blood flow reserve and perfusion-metabolism mismatch.surrogate

Congestive heart failure is associated with impaired myocardial blood flow reserve and flow-metabolism mismatch, suggesting a reciprocal relationship where left ventricular dysfunction may induce ischemia.

Cite This Study

Veldhuisen et al. (1998) studied this question.

synapsesocial.com/papers/6a8baabe2448cb7c68339080 https://doi.org/10.1097/00005344-199800003-00008

Topics

Heart failure HFrEF treatment Dual antiplatelet therapy Women and heart disease

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Ischemia and Left Ventricular Dysfunction: A Reciprocal Relation?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Ischemia and Left Ventricular Dysfunction: A Reciprocal Relation?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider