PURPOSE: To determine the prevalence of hyperhomocystinemia in patients with pseudoexfoliation glaucoma. PATIENTS AND METHODS: This prospective study included 30 patients with glaucoma and 30 age-matched controls with no history of ocular disease who were undergoing routine physical checkups. Plasma homocysteine levels of all the study participants were determined using high-performance liquid chromatography, and values exceeding 15 micromol/L were considered elevated. RESULTS: The mean plasma homocysteine level was 16.80 +/- 3.20 and 12.39 +/- 1.97 micromol/L in glaucoma patients and controls, respectively (P<0.0001). Fifteen glaucoma patients (50%) had hyperhomocystinemia compared with 3 controls (10%) (P=0.0015). CONCLUSION: Hyperhomocystinemia may be associated with pseudoexfoliation glaucoma, which may partially explain the increased risk of vascular diseases among patients with pseudoexfoliation syndrome.
No takes yet. Share an insight, caveat, or question.
Leibovitch et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: