Why the study?
Does hyperlipidemia alter the pharmacokinetics and pharmacodynamics of a single oral dose of propranolol?
Population
n=48 subjects divided into four groups: healthy volunteers, hypercholesterolemic patients…
Comparison
Propranolol 80 mg oral single dose vs Healthy volunteers (normolipemic subjects)
Design
Cohort
Follow-up
12 hours
Authors
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Propranolol PK changes in hypertriglyceridemia spare acute PD responses; hypothesis-generating and should not yet alter dosing.
Does hyperlipidemia alter the pharmacokinetics and pharmacodynamics of a single oral dose of propranolol?
While hypertriglyceridemia significantly alters the pharmacokinetics of propranolol, it does not affect its pharmacodynamic effects on heart rate and blood pressure.
Wójcicki et al. (1999) studied this question.
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