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Lidocaine-hydrochloride-induced central nervous system (CNS) toxic effects in a patient with liver disease occurred after an intravenous infusion of the drug in a dose much smaller than is tolerated by patients with normal hepatic function. To the best of our knowledge, this is the first clinical description of the CNS manifestations of lidocaine in a patient with hepatic insufficiency.
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Richard F. Selden (1967) studied this question.
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