Chicken pox infection (varicella zoster virus) and acute monoarthritis: evidence against a direct viral mechanism.

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Why the study?

Is acute monoarthritis concurrent with chicken pox caused by direct viral replication inside the joint?

Population

9 year old boy with acute monoarthritis of the left knee concurrent with varicella zoster virus rash

Design

Case_report

Authors

Discussion

Acute monoarthritis with varicella unlikely from direct intra-articular replication; leaves open immune-mediated mechanisms for study.

Is acute monoarthritis concurrent with chicken pox caused by direct viral replication inside the joint?

Population

9 year old boy with acute monoarthritis of the left knee concurrent with varicella zoster virus (VZV) rash (n=1)

Intervention

VZV DNA hybridisation of cells within synovial fluid and synovial membrane, and virus isolation

Outcome

Evidence of intracellular virus or viral replication inside the swollen jointsurrogate

Acute monoarthritis associated with chicken pox does not appear to be driven by direct viral replication within the joint.

Fink et al. (1992) studied this question.

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