What question did this study set out to answer?

To review the structural and functional neurobiology of neurofilament proteins and evaluate the mechanisms underlying their release, degradation, and application as biomarkers of neuronal damage.

March 13, 2020BrainOpen Access

Neurofilaments: neurobiological foundations for biomarker applications

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Authors

AGArie GafsonBiogen (United States)NBNicolas R. BarthélemyWashington University in St. Louis PBPascale BomontUniversité Claude Bernard Lyon 1

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Implication

Narrative review outlines the neurobiology and turnover kinetics of neurofilaments in human neurological diseases, highlighting their clinical utility as biomarkers of neuronal injury.

Key Points

To review the structural and functional neurobiology of neurofilament proteins and evaluate the mechanisms underlying their release, degradation, and application as biomarkers of neuronal damage.
Synthesized evidence on neurofilament protein structure, degradation, turnover kinetics, and functional roles, including synaptic activity.
Evaluated clinical utility and technical validity of quantifying neurofilament concentrations in cerebrospinal fluid and blood across neurological diseases.
Neurofilaments contribute directly to synaptic architecture and physiology, challenging the traditional view of these proteins as passive structural scaffolding.
Elevations of neurofilament concentrations in cerebrospinal fluid and blood reliably reflect acute and chronic axonal disruption across multiple neurodegenerative disorders.
Standardizing clinical biomarker interpretation requires characterizing human in vivo turnover kinetics and normal intermediate filament clearance pathways.

Cite This Study

Gafson et al. (2020) studied this question.

synapsesocial.com/papers/6a8bc217039371f2a389655a https://doi.org/10.1093/brain/awaa098

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Implication

Narrative review outlines the neurobiology and turnover kinetics of neurofilaments in human neurological diseases, highlighting their clinical utility as biomarkers of neuronal injury.

Neurofilaments: neurobiological foundations for biomarker applications

Discussion

Member takes

Implication

Key Points

Cite This Study

Neurofilaments: neurobiological foundations for biomarker applications

Discussion

Member takes

Implication

Key Points

Cite This Study

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