An investigation was made of the effects of various factors and drugs on the total soluble nonprotein sulfhydryl content of rat liver. It was found that the combination of fasting, hydration, and bilateral tourniquets resulted in the lowest mg. % of the sulfhydryl content. Acetylsalicylic acid 500-600 mg./Kg., salicylamide 150 mg./Kg., and acetophenetidin 600 mg./Kg., inhibited the decrease of the total nonprotein sulfhydryl content in the liver of the rat subjected to stress. Sodium pheno-barbital 50 mg./Kg., and morphine sulfate 10 mg./Kg., also gave similar results. Aminopyrine 100-600 mg./Kg., and sodium salicylate 200-750 mg./Kg., failed to inhibit the decrease of sulfhydryl content of the stressed rat liver. At the large doses, both aminopyrine and sodium salicylate proved fatal to the animals tested. It was possible to demonstrate that sodium salicylate at the 200 mg./Kg. dose level caused a decrease of the sulfhydryl content without the use of tourniquets. This study indicates that the protection of the total nonprotein sulfhydryl content of the stressed rat liver is not of a high degree of specificity.
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TAKESUE et al. (1957) studied this question.
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