Animal study demonstrates that anti-anaerobic parenteral antibiotics promote Candida glabrata gut colonization in mice, suggesting intestinal anaerobes protect against fungal overgrowth.
We examined the effect of antibiotic treatment on establishment of intestinal colonization by Candida glabrata in adult mice. Subcutaneous ceftriaxone, piperacillin-tazobactam, clindamycin, and metronidazole promoted increased density of stool colonization, whereas cefepime, levofloxacin, and aztreonam did not. These findings suggest that antibiotics that inhibit intestinal anaerobes promote C. glabrata colonization.
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Pultz et al. (2004) studied this question.
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