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October 1, 2000British Journal of PharmacologyOpen Access

Nitric oxide and sodium nitroprusside‐induced relaxation of the human umbilical artery

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Population

Human umbilical artery rings pre-contracted with the thromboxane mimetic U46619 or with 5-hydroxytryptamine…

Comparison

Nitric oxide (NO) and sodium nitroprusside (SNP) vs Various pharmacological inhibitors and varying…

Design

Preclinical

Authors

FLFina LovrenSt. Michael's HospitalCTChris R. TriggleVascular / Pulmonary Vascular

Discussion

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Implication

Differential NO/SNP mechanisms in HUA suggest selective vasodilator targeting; leaves open human in vivo validation before any clinical application.

Structured PICO

P
Population
Human umbilical artery (HUA) rings pre-contracted with the thromboxane mimetic U46619 or with 5-hydroxytryptamine (5-HT), and pretreated with indomethacin
I
Intervention
Nitric oxide (NO) and sodium nitroprusside (SNP)
C
Comparator
Various pharmacological inhibitors (ODQ, TEA, 4-AP, charybdotoxin, iberiotoxin) and varying oxygen tensions
O
Outcome
Vascular relaxation (measured by pEC50 and Emax)surrogate

Nitric oxide and sodium nitroprusside induce relaxation in human umbilical arteries through distinct mechanistic pathways, with NO uniquely involving potassium channels and cGMP-independent mechanisms.

Cite This Study

Lovren et al. (2000) studied this question.

synapsesocial.com/papers/6a8bc79fd5d4290f64f4850bhttps://doi.org/10.1038/sj.bjp.0703588
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vascular reactivity to endothelium-derived relaxing factor in human umbilical artery at term pregnancy1997 · 6 citations
  2. 2Cyclic GMP‐dependent and cyclic GMP‐independent actions of nitric oxide on the renal afferent arteriole1998 · 36 citations
  3. 3Impaired cyclic nucleotide‐mediated vasorelaxation may contribute to closure of the human umbilical artery after birth1992 · 16 citations
  4. 4Acetylcholine‐induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase1999 · 128 citations
  5. 5Characterization and actions of human umbilical endothelium derived relaxing factor1991 · 81 citations