Why the study?
Is myotonia congenita associated with malignant hyperthermia susceptibility?
Is myotonia congenita associated with malignant hyperthermia susceptibility?
This case series suggests a potential association between myotonia congenita and malignant hyperthermia susceptibility.
Suggests possible myotonia congenita–malignant hyperthermia link in this family; hypothesis-generating and should not change practice.
We report a family in which two sisters with myotonia congenita (MyC) were referred for malignant hyperthermia (MH) evaluation after each developed muscle rigidity with anesthesia. Halothane contracture testing of skeletal muscle in both was consistent with MH susceptibility. A third sister without clinical evidence of MyC was negative on contracture testing. These results suggest an association between MyC and MH susceptibility.
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Heiman‐Patterson et al. (1988) studied this question.
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