What question did this study set out to answer?

To determine the individual contributions of specific pneumococcal proteins to bacterial pathogenesis and evaluate their potential as protective vaccine antigens.

March 1, 1997Microbial Drug Resistance

Molecular Analysis of Putative Pneumococcal Virulence Proteins

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Authors

JPJames C. PatonBrigham and Women's Hospital ABAnne M. BerryUniversity of North Carolina at Chapel Hill RLR.A.C. LockUniversity of Leicester

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Implication

Preclinical animal study uncovers the pathogenic roles and protective efficacy of pneumococcal surface proteins in mice, highlighting their utility as candidate vaccine antigens.

Key Points

To determine the individual contributions of specific pneumococcal proteins to bacterial pathogenesis and evaluate their potential as protective vaccine antigens.
Generated targeted chromosomal gene mutations in pneumococci for pneumolysin, two distinct neuraminidases, autolysin, hyaluronidase, and the 37 kDa pneumococcal surface adhesin A.
Assessed changes in virulence between wild-type and gene-mutated pneumococcal strains in animal infection models.
Immunized mice with purified candidate protein antigens and subsequently challenged them with virulent pneumococci.
Targeted gene disruption of individual surface and toxin proteins demonstrably altered pneumococcal virulence in animal models.
Immunization of mice with purified candidate proteins conferred protection against subsequent challenge with virulent pneumococci.

Cite This Study

Paton et al. (1997) studied this question.

synapsesocial.com/papers/6a8bc8f460c8c47a9ee3e70e https://doi.org/10.1089/mdr.1997.3.1

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Implication

Preclinical animal study uncovers the pathogenic roles and protective efficacy of pneumococcal surface proteins in mice, highlighting their utility as candidate vaccine antigens.

Molecular Analysis of Putative Pneumococcal Virulence Proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

Molecular Analysis of Putative Pneumococcal Virulence Proteins

Discussion

Member takes

Implication

Key Points

Cite This Study

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