Why the study?
The mortality rate and efficacy of ICD therapy in reducing sudden cardiac death in Chinese patients with Class I indication for ICD were not well established.
Does ICD implantation reduce mortality and sudden cardiac death in Chinese patients with a Class I indication for ICD?
Cohort (n=497)
Yes
Does ICD implantation reduce mortality and sudden cardiac death in Chinese patients with a Class I indication for ICD?
ICD therapy effectively reduces mortality in Chinese patients with a Class I indication for ICD implantation, confirming the real-world benefit of guideline-directed device therapy in this population.
ICD associated with lower mortality in Chinese Class I patients; supports real-world use but leaves open need for randomized confirmation.
Preventive Effectiveness of Implantable Cardioverter. Introduction: This prospective and multicenter trial of the implantable cardioverter‐defibrillator (ICD) aimed to evaluate the mortality rate (including sudden cardiac death [SCD]) and the efficacy of ICD in Chinese patients with high risk of sudden death. Methods and Results : This trial was conducted in 31 centers in China. We enrolled 497 patients who fulfilled Class I indication for ICD (2002 ACC/AHA/NASPE guideline). All patients were followed‐up at 3, 6, and 12 months. Clinical characteristics and echocardiographic parameters were collected at baseline and follow‐up; Kaplan–Meier survival analysis was performed. Among 497 enrolled patients with Class I indication of ICD therapy, 112 (22.5%) agreed to and received ICD implantation (ICD group). The remaining 385 patients who were not available for ICD therapy were designated as the non‐ICD group. During a mean follow‐up of 11 ± 3 months, there were a total of 38 deaths, 2 in the ICD group with a mortality of 1.8% and 36 in the non‐ICD group, with a mortality of 9.4% and 26 due to SCD. The overall survival rate was 93% at 3 months of follow‐up, 91% at 6 months, and 89% at 12 months, with an incidence of SCD of 5%, 7%, and 8% at 3, 6, and 12 months, respectively. Conclusions : In patients with Class I indication of ICD implantation, the total mortality and incidence of SCD were high. ICD therapy can effectively reduce the mortality in such patients. (J Cardiovasc Electrophysiol, Vol. 23, pp.
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Hua et al. (2012) conducted a cohort in High risk of sudden death (n=497). Implantable cardioverter-defibrillator (ICD) vs. Non-ICD therapy was evaluated on Total mortality.
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