November 1, 2000Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Pulsatile Stretch–Induced Extracellular Signal–Regulated Kinase 1/2 Activation in Organ Culture of Rabbit Aorta Involves Reactive Oxygen Species

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Why the study?

Does pulsatile stretch activate ERK1/2 in an organ culture model of rabbit aorta?

Structured PICO

Does pulsatile stretch activate ERK1/2 in an organ culture model of rabbit aorta?

Population

Organ culture model of rabbit aorta

Intervention

Pulsatile stretch (10% variation in vessel diameter) in vessels maintained at 80 mm Hg for 24 hours

Comparator

Control aortas without pulsatility (steady overstretch)

Outcome

ERK1/2 activitysurrogate

Pulsatile stretch activates ERK1/2 in the arterial wall via oxygen-derived free radical production, utilizing pathways distinct from those induced by steady overstretch.

Discussion

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Implication

Pulsatile stretch may activate ERK1/2 in arteries; hypothesis-generating in rabbit organ culture, leaves open in vivo and clinical relevance.

Cite This Study

Lehoux et al. (2000) studied this question.

synapsesocial.com/papers/6a8bcb24b676b7d1a2fb7cdc https://doi.org/10.1161/01.atv.20.11.2366

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Implication

Pulsatile stretch may activate ERK1/2 in arteries; hypothesis-generating in rabbit organ culture, leaves open in vivo and clinical relevance.

Pulsatile Stretch–Induced Extracellular Signal–Regulated Kinase 1/2 Activation in Organ Culture of Rabbit Aorta Involves Reactive Oxygen Species

Structured PICO

Discussion

Implication

Cite This Study

Pulsatile Stretch–Induced Extracellular Signal–Regulated Kinase 1/2 Activation in Organ Culture of Rabbit Aorta Involves Reactive Oxygen Species

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider