What question did this study set out to answer?

Determine the effects of daily intranasal administration of estradiol-17β, progesterone, or norethisterone on circulating testosterone levels and sperm production in adult male rhesus monkeys.

May 1, 1980Biology of Reproduction

Effects of Intranasal Administration of Hormonal Steroids on Serum Testosterone and Spermatogenesis in Rhesus Monkey (Macaca mulatta)

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Authors

TKT. C. Anand KumarLMU Klinikum ASAtam SehgalBabasaheb Bhimrao Ambedkar University GDGyula DávidSemmelweis University

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Implication

Animal experiment demonstrates reduced testosterone and arrested spermatogenesis in male rhesus monkeys, indicating intranasal steroid delivery may serve as a male contraceptive approach.

Key Points

Determine the effects of daily intranasal administration of estradiol-17β, progesterone, or norethisterone on circulating testosterone levels and sperm production in adult male rhesus monkeys.
Administered daily intranasal sprays of estradiol-17β, progesterone, or norethisterone at a dose of 30 μg/day for 60 days to adult male rhesus monkeys (Macaca mulatta, body weight 7.5–11 kg).
Assessed changes in testicular size, spermatogenesis, and serum testosterone against solvent-treated control monkeys.
Intranasal administration of all three hormonal steroids induced a decrease in testicular size and complete arrest of spermatogenesis over 60 days.
Serum testosterone levels were significantly reduced in steroid-treated monkeys, whereas solvent-treated controls showed no alterations.

Cite This Study

Kumar et al. (1980) studied this question.

synapsesocial.com/papers/6a8bcbecb676b7d1a2fb7cfa https://doi.org/10.1095/biolreprod22.4.935

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Implication

Animal experiment demonstrates reduced testosterone and arrested spermatogenesis in male rhesus monkeys, indicating intranasal steroid delivery may serve as a male contraceptive approach.

Effects of Intranasal Administration of Hormonal Steroids on Serum Testosterone and Spermatogenesis in Rhesus Monkey (Macaca mulatta)

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of Intranasal Administration of Hormonal Steroids on Serum Testosterone and Spermatogenesis in Rhesus Monkey (Macaca mulatta)

Discussion

Member takes

Implication

Key Points

Cite This Study

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