What question did this study set out to answer?

To determine the influence of the timing of ovariectomy (spaying) on the induction of delayed implantation in adult mice treated with progesterone.

December 1, 1966Reproduction

Delayed Implantation in the Spayed, Progesterone Treated Adult Mouse

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Authors

KYK. YoshinagaTokyo University of Science CAC. E. AdamsThe Century Foundation

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Implication

Animal study investigates delayed implantation timing in spayed, progesterone-treated adult mice, highlighting hormonal controls of embryo attachment.

Key Points

To determine the influence of the timing of ovariectomy (spaying) on the induction of delayed implantation in adult mice treated with progesterone.
Examined adult female mice subjected to ovariectomy at different days of early pregnancy.
Administered exogenous progesterone replacement therapy post-ovariectomy to assess blastocyst implantation outcomes.
Addressed whether early spaying (days 1–2) versus later spaying (day 4) consistently induces delayed implantation in mice, paralleling disputed mechanisms in rats.
Established baseline physiological responses to timing of hormonal deprivation to clarify discrepancies previously attributed to incomplete ovariectomy.

Cite This Study

Yoshinaga et al. (1966) studied this question.

synapsesocial.com/papers/6a8bcc3b3fd21775a533bb97 https://doi.org/10.1530/jrf.0.0120593

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Implication

Animal study investigates delayed implantation timing in spayed, progesterone-treated adult mice, highlighting hormonal controls of embryo attachment.

Delayed Implantation in the Spayed, Progesterone Treated Adult Mouse

Discussion

Member takes

Implication

Key Points

Cite This Study

Delayed Implantation in the Spayed, Progesterone Treated Adult Mouse

Discussion

Member takes

Implication

Key Points

Cite This Study

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