Studies in Diabetes Mellitus. Ii. The Occurrence of a Diuresis in Diabetic Persons Exposed to Stressful Life Situations, With Experimental Observations on Its Relation to the Concentration of Glucose in Blood and Urine 1

It has been known for many years that the ad- ministration of large amounts of glucose to per- sons with diabetes mellitus may lead to a diuresis. Recent work has amply demonstrated that this effect is attributable to the fact that in the pres- ence of high concentrations of urinary glucose or any other solute there is a limit to the amount of water the renal tubule can absorb-a point where the osmotic pressure of the urine outweighs the work capacity of the tubular epithelium. Brodsky, Rapoport, and West (1) have shown that in this respect the kidney of the diabetic behaves toward glucose in the same manner as the kidney of the non-diabetic individual.