Why the study?
Does streptozotocin-induced diabetes increase the number and severity of ventricular arrhythmias following coronary artery occlusion in rats?
Does streptozotocin-induced diabetes increase the number and severity of ventricular arrhythmias following coronary artery occlusion in rats?
In a rat model, streptozotocin-induced diabetes does not appreciably increase susceptibility to ventricular arrhythmias following acute coronary occlusion.
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No increased arrhythmia risk in streptozotocin diabetic rat ischemia; leaves open relevance to human diabetic patients post-MI.
The following investigation was designed to assess whether or not streptozotocin diabetes has an influence on the number and severity of ventricular arrhythmias following coronary artery occlusion in the conscious rat. In addition, electrocardiogram and haemodynamic data were compared between streptozotocin groups and control. Diabetes was induced in male Sprague-Dawley rats with streptozotocin (55 mg/kg iv) and left anterior descending coronary artery ligation was performed either 6 or 9 weeks later. Rats were allowed to recover from preparative surgery for 1 week prior to ligation. Streptozotocin diabetes (untreated or insulin controlled) appeared to have little influence on the variables tested. When exposed to equivalent degrees of ischaemia (the rat is a microangiopathy-resistant species), the streptozotocin diabetic rat heart was not appreciably more prone to arrhythmias of any type compared with control.
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Beatch et al. (1988) studied this question.
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