Population
Hematopoietic stem cells (HSCs) in ex vivo culture and in vivo models
Design
Preclinical
Authors
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Does not support clinical HSC expansion protocols; leaves open whether αvβ3 ligation enhances human stem cell grafts.
Integrin-αvβ3 signaling, dependent on thrombopoietin, is essential for maintaining the long-term repopulating activity of hematopoietic stem cells both in vivo and during ex vivo culture.
Umemoto et al. (2011) studied this question.
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