Key result
Radiation-induced cardiac death remains low at 10 years with mean heart dose under ~3.3 Gy.
Why the study?
The authors sought to assess whether women treated with breast/chest wall RT who died of cardiovascular disease violated international QUANTEC cardiac guidelines.
Does heart V25Gy dosimetry predict cardiovascular death in women receiving adjuvant breast/chest wall radiotherapy?
Does heart V25Gy dosimetry predict cardiovascular death in women receiving adjuvant breast/chest wall radiotherapy?
Current QUANTEC guidelines (V25Gy <10%) may not adequately predict or prevent cardiovascular death in women receiving modern breast radiotherapy, as no CVD deaths had V25Gy >10%.
Answers are grounded in this paper and cite their sources.
Does not identify cardiac dosimetry as a CVD predictor after modern breast RT; leaves open relevance of current V25Gy constraints for longer-term outcomes.
Highlights • Cardiovascular risk factors predict for cardiac death after breast radiotherapy.• Cardiovascular risk factors should be modified in breast cancer patients.• Radiation induced cardiac death at 10-years is low if mean heart dose is <3.3 Gy.• Radiation induced cardiac death at 10-years is low if maximum LAD dose is <45.4 Gy.• Studies are needed to evaluate heart and LAD constraints in the CT-planning era.
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Beaton et al. (2019) conducted a review in Breast cancer requiring radiotherapy. Breast radiotherapy was evaluated on Radiation induced cardiac death. Radiation-induced cardiac death at 10 years after breast radiotherapy is low if mean heart dose is <3.3 Gy and maximum LAD dose is <45.4 Gy.
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