Long-term Cardiovascular Outcomes Among Endometrial Cancer Survivors in a Large, Population-Based Cohort Study
Why the study?
Does endometrial cancer survivorship increase the risk of long-term cardiovascular outcomes compared to the general population?
Population
13,151 women, comprising 2,648 endometrial cancer survivors diagnosed between 1997 and 2012 and 10,503…
Comparison
Endometrial cancer survivorship vs Age-matched women from the general population
Design
Cohort
Follow-up
>10 years
Authors
Discussion
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Member takes
Implication
Supports extended CV monitoring in endometrial cancer survivors; leaves open whether targeted interventions reduce events.
Structured PICO
Does endometrial cancer survivorship increase the risk of long-term cardiovascular outcomes compared to the general population?
P
Population
13,151 women, comprising 2,648 endometrial cancer survivors diagnosed between 1997 and 2012 and 10,503 age-matched women from the general population in the United States.
I
Intervention
Endometrial cancer survivorship (including subgroups receiving surgery alone vs. surgery plus radiation therapy and/or chemotherapy)
C
Comparator
Age-matched women from the general population
O
Outcome
Cardiovascular disease diagnoses (including phlebitis, thrombophlebitis, thromboembolism, pulmonary heart disease, and atrial fibrillation) assessed at 1 to 5 years, >5 to 10 years, and >10 years after cancer diagnosishard clinical
Endometrial cancer survivors are at significantly higher risk for long-term cardiovascular outcomes, particularly venous thromboembolism and atrial fibrillation, highlighting the need for prolonged cardiovascular monitoring.
Cite This Study
Soisson et al. (2018) studied this question.