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January 8, 2018The Journal of Clinical Endocrinology & MetabolismOpen Access

Plasma 25-Hydroxyvitamin D and Mortality in Patients With Suspected Stable Angina Pectoris

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Why the study?

Is plasma 25-hydroxyvitamin D concentration associated with all-cause and cardiovascular mortality in patients with suspected stable angina pectoris?

Population

4,114 white patients suspected of having stable angina pectoris

Comparison

Higher plasma 25-hydroxyvitamin D concentrations vs Lowest plasma 25-hydroxyvitamin D concentration

Design

Cohort

Follow-up

mean 11.9 ± 3.0 years

Authors

EDEirik DegerudNational Institute of Occupational HealthONOttar NygårdHaukeland University HospitalSVStefan de VogelOslo University Hospital

Discussion

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Implication

Higher 25OHD associated with lower mortality in suspected stable angina; hypothesis-generating and should not change practice without RCTs.

Structured PICO

Is plasma 25-hydroxyvitamin D concentration associated with all-cause and cardiovascular mortality in patients with suspected stable angina pectoris?

P
Population
4,114 white patients suspected of having stable angina pectoris
I
Intervention
Higher plasma 25-hydroxyvitamin D (25OHD) concentrations (quartiles 2, 3, and 4)
C
Comparator
Lowest plasma 25-hydroxyvitamin D (25OHD) concentration (first quartile)
O
Outcome
All-cause mortality and cardiovascular mortalityhard clinical

Plasma 25-hydroxyvitamin D concentrations have a U-shaped association with all-cause mortality and an inverse association with cardiovascular mortality in patients with suspected stable angina.

Cite This Study

Degerud et al. (2018) studied this question.

synapsesocial.com/papers/6a8bd116bc51310b2bdec8e0https://doi.org/10.1210/jc.2017-02328

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 11,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system2002 · 1,629 citations
  2. 2Determination of vitamins A, D and E in a small volume of human plasma by a high‐throughput method based on liquid chromatography/tandem mass spectrometry2011 · 76 citations
  3. 3Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality2008 · 1,217 citations
  4. 4A New Equation to Estimate Glomerular Filtration Rate2009 · 26,148 citations
  5. 5Cosinor modelling of seasonal variation in 25-hydroxyvitamin D concentrations in cardiovascular patients in Norway2015 · 43 citations