Why the study?
Pre-operative optimisation comprises heterogeneous interventions to improve peri-operative outcomes, but the evidence base in the developing world was not well understood.
Population
409 trials representing 51 countries and 89,389 randomly allocated participants
Comparison
Trials classified by Human Developmental Index (HDI) of recruitment country
Design
Systematic review of Cochrane reviews
Authors
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Pre-operative optimisation evidence applies mainly to high-HDI populations; challenges generalizability and supports expansion of multinational trials.
Low- and middle-HDI countries are poorly represented in systematically reviewed evidence on pre-operative optimisation, highlighting a significant gap in global peri-operative research.
Toit et al. (2018) studied this question.
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