Key result
Perioperative administration of ACEIs or ARBs did not significantly reduce perioperative mortality compared to placebo (2.7% vs 1.6%; RR 1.61; 95% CI 0.44-5.85).
Why the study?
Does perioperative administration of ACEIs or ARBs prevent mortality and morbidity in adults undergoing surgery under general anaesthesia?
Population
7 RCTs pooling 571 adults undergoing surgery under general anaesthesia. Excluded: procedures requiring local…
Comparison
Perioperative administration of ACEIs or ARBs. vs Placebo.
Design
Meta-analysis
Follow-up
perioperative
Authors
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Does not support routine perioperative ACEI/ARB initiation; leaves open need for larger trials given inconclusive data.
Systematic Review (n=571)
Does perioperative administration of ACEIs or ARBs prevent mortality and morbidity in adults undergoing surgery under general anaesthesia?
Relative Risk: 1.61 (95% CI 0.44–5.85)
Absolute Event Rate: 2.7% vs 1.6%
There is currently insufficient high-quality evidence to support the routine perioperative initiation of ACEIs or ARBs for preventing mortality or morbidity in adults undergoing general anaesthesia.
Zou et al. (2016) conducted a systematic review in Surgery under general anaesthesia (n=571). Perioperative ACEIs or ARBs vs. Placebo was evaluated on Perioperative mortality (RR 1.61, 95% CI 0.44 to 5.85). Perioperative administration of ACEIs or ARBs did not significantly reduce perioperative mortality compared to placebo (2.7% vs 1.6%; RR 1.61; 95% CI 0.44-5.85).
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