Antibody titres to heat shock protein 27 are elevated in patients with acute coronary syndrome
Why the study?
Are anti-Hsp27 IgG titres elevated in patients with acute coronary syndrome compared to matched controls?
Population
175 subjects, comprising 94 patients admitted with acute coronary syndrome and 81 age- and sex-matched…
Design
Case-control
Follow-up
Up to 24 hours (first and second 12 h after symptom onset)
Authors
Discussion
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Member takes
Implication
Anti-Hsp27 titres associate with early ACS; hypothesis-generating for biomarker utility and requires prospective validation before any clinical use.
Structured PICO
Are anti-Hsp27 IgG titres elevated in patients with acute coronary syndrome compared to matched controls?
P
Population
175 subjects, comprising 94 patients admitted with acute coronary syndrome (42 with myocardial infarction, 52 with unstable angina) and 81 age- and sex-matched control subjects.
C
Comparator
Age- and sex-matched control subjects
O
Outcome
Anti-Hsp27 IgG titres in the first and second 12 h after the onset of symptomssurrogate
Serum antibody titres to Hsp27 rise and fall rapidly after the onset of acute coronary syndrome, suggesting potential utility as an early marker of myocardial ischaemia.
Cite This Study
Ghayour‐Mobarhan et al. (2008) studied this question.